Translation of immunomodulatory therapy to treat chronic heart failure: Preclinical studies to first in human.

H David HumesKeith D AaronsonDeborah A BuffingtonHani N SabbahAngela J WestoverLenar T YessayanBalazs SzamosfalviFrancis D Pagani

Published in: PloS one (2023)

This translational research study demonstrates a promising immunomodulatory approach to improve cardiac performance in HFrEFHFrEF and supports the important role of inflammation in the progression of HFHF.

Keyphrases

endothelial cells
left ventricular
heart failure
induced pluripotent stem cells
pluripotent stem cells
stem cells
mesenchymal stem cells
bone marrow
replacement therapy