Automated assessment of bone changes in cross-sectional micro-CT studies of murine experimental osteoarthritis.
Patricia Das Neves BorgesTonia L VincentMassimo MarenzanaPublished in: PloS one (2017)
Our automated methods for assessing bone changes in murine periarticular bone are rapid, quantitative, and highly accurate, and promise to be a useful tool in future preclinical studies of OA progression and treatment. The current approaches were developed specifically for cross-sectional micro-CT studies but could be applied to longitudinal studies.
Keyphrases
- cross sectional
- case control
- bone mineral density
- computed tomography
- machine learning
- high throughput
- soft tissue
- high resolution
- image quality
- rheumatoid arthritis
- bone loss
- knee osteoarthritis
- postmenopausal women
- bone regeneration
- stem cells
- magnetic resonance imaging
- magnetic resonance
- current status
- quantum dots
- single cell
- combination therapy
- pet ct