Pharmacokinetic Evaluation of Cefazolin in the Cerebrospinal Fluid of Critically Ill Patients.

Alison R NovakMartin Kršák Tyree Heath KiserRobert T NeumannLuis Cava PradoKyle C Molina Scott W Mueller

Published in: Open forum infectious diseases (2021)

. Further clinical trials are required to confirm a role in therapy for cefazolin. Population-based pharmacokinetic-pharmacodynamic modeling may suggest an optimal cefazolin regimen for the treatment of central nervous system infections.

Keyphrases

cerebrospinal fluid
clinical trial
randomized controlled trial
combination therapy
open label
replacement therapy
study protocol
double blind