Protective Role of Optineurin Against Joint Destruction in Rheumatoid Arthritis Synovial Fibroblasts.

Wen Shi Lee Masaru Kato Eri Sugawara Michihiro KonoYuki KudoMichihito Kono Yuichiro FujiedaToshiyuki BohgakiOlga AmengualKenji OkuShinsuke YasudaTomohiro OnoderaNorimasa IwasakiTatsuya Atsumi

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

OPTN plays a protective role in RA when it is up-regulated in RASFs in the presence of proinflammatory cytokines. Absence of OPTN might worsen RA by generating a joint-destructive state, as indicated by evidence of increased RANKL expression on RASFs and subsequent osteoclast differentiation.

Keyphrases

rheumatoid arthritis
disease activity
ankylosing spondylitis
poor prognosis
bone loss
interstitial lung disease
systemic lupus erythematosus
extracellular matrix
nuclear factor
systemic sclerosis
toll like receptor