Login / Signup

Cell plasticity in epithelial homeostasis and tumorigenesis.

Julia VargaFlorian R Greten
Published in: Nature cell biology (2017)
The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and the epithelial-mesenchymal transition-two distinct, yet closely related, forms of plasticity with fundamental roles in homeostasis and cancer.
Keyphrases
  • epithelial mesenchymal transition
  • cell fate
  • stem cells
  • papillary thyroid
  • oxidative stress
  • single cell
  • signaling pathway
  • cell therapy
  • transforming growth factor