The TERT Promoter is Polycomb-Repressed in Neuroblastoma Cells with Long Telomeres.

Mindy K Graham Bei-Si Xu Christine Davis Alan K Meeker Christopher M Heaphy Srinivasan Yegnasubramanian Michael A Dyer Maged Zeineldin

Published in: Cancer research communications (2024)

The epigenetic landscape of the TERT locus is unique in neuroblastoma. The DNA at the TERT locus, unlike other cancer cells and similar to normal cells, are hypomethylated in telomerase-positive neuroblastoma cells. The TERT locus is repressed by polycomb repressive complex-2 complex in neuroblastoma cells that have long telomeres and do not express TERT. Long telomeres in neuroblastoma cells are also associated with repressive chromatin states at the chromosomal termini, suggesting TPE.

Keyphrases

induced apoptosis
cell cycle arrest
gene expression
oxidative stress
cell death
single cell
copy number
pi k akt