Identification and characterisation of novel CAR-T cells to target IL13Rα2 positive human glioma in vitro and in vivo.

Pamela LelandHeba DegheidyAshley LeaSteven R BauerRaj K PuriBharat H Joshi

Published in: Clinical and translational medicine (2024)

Taken together, we conclude that the novel scFv-IL-13Rα2 CAR-T cell therapy may offer an effective therapeutic option after designing a careful pre-clinical and clinical study.

Keyphrases

cell therapy
induced apoptosis
endothelial cells
stem cells
mesenchymal stem cells
cell cycle arrest
pluripotent stem cells
endoplasmic reticulum stress
signaling pathway
double blind
bone marrow
bioinformatics analysis
pi k akt