Effectiveness of Different Antimicrobial Strategies for Staphylococcal Prosthetic Joint Infection: Results From a Large Prospective Registry-Based Cohort Study.
Henk ScheperRobert J P van der WalRachid MahdadStefan KeizerNathalie M DelfosJoris C T van der LugtKarin Ellen VeldkampPeter A NolteMasja LeendertseLuc B S GelinckFemke P N MollemaEmile F SchippersHanke G Wattel-LouisLeo G VisserRob G H H NelissenMark G J de BoerPublished in: Open forum infectious diseases (2022)
A short-term rifampicin strategy with either clindamycin or flucloxacillin and only 5 days of rifampicin was found to be as effective as traditional long-term rifampicin combination therapy. A randomized controlled trial is needed to further address efficacy and safety of alternative treatment strategies for staphylococcal PJI.