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Decline of maternal antibodies to small ruminant lentivirus in goat kids.

Michał CzopowiczOlga Szaluś-JordanowMarcin MickiewiczAgata MorozLucjan WitkowskiIwona Markowska-DanielDaria ReczyńskaEmilia BagnickaJarosław Kaba
Published in: Animal science journal = Nihon chikusan Gakkaiho (2018)
We carried out this study to determine for how long small ruminant lentivirus (SRLV)-specific antibodies can be detected by three commercial ELISA kits in goat kids after suckling infected does in field conditions. Forty-one kids born to SRLV-seropositive asymptomatic does were blood sampled prior to colostrum consumption, and then weekly for 6 months in total. The sera were screened with three commercial ELISA kits: whole-virus ELISA (wELISA), recombinant transmembrane and capsid antigen ELISA (TM/CA-ELISA), and surface antigen ELISA (SU-ELISA). All but one kid were seronegative in all three ELISAs right after birth. At the age of 1 week all kids turned seropositive in wELISA, 39 kids (95%) in TM/CA-ELISA, and 35 kids (85%) in SU-ELISA. All seropositive kids turned seronegative in wELISA by the 15th week, and in SU-ELISA by the 19th week (median of 8 weeks in both ELISA), whereas in TM/CA-ELISA five kids (13% of 39 initially seropositive) were still seropositive at the age of 6 months (median of 11 weeks). Antibody levels at the age of 1 week proved significantly linked to the duration of maternal antibodies in all three ELISAs and could be employed to predict for how long maternal antibodies would remain detectable.
Keyphrases
  • monoclonal antibody
  • randomized controlled trial
  • clinical trial
  • physical activity
  • pregnant women
  • cell free
  • low birth weight
  • weight gain