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Exploratory assessment of serological tests to determine antibody titer against SARS-CoV-2: Appropriateness and limits.

Alessandra ColombiniMarco ViganòTomaiuolo RossellaChiara Di RestaFrancesca CoreaEleonora SabettaDavide FerrariElena De VecchiSestina Maria SpanòGiuseppe Banfi
Published in: Journal of clinical laboratory analysis (2022)
The definition of antibodies in the WHO standard and the analysis of serum samples allowed for the identification of the appropriateness of serological tests in each diagnostic setting, increasing the effectiveness of the resulting laboratory data. Furthermore, we found that it would be optimal to produce new international standards against the S1 domain and RBD of the SARS-CoV-2 spike protein for a more effective serological monitoring of vaccination.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • randomized controlled trial
  • systematic review
  • electronic health record
  • big data
  • small molecule
  • deep learning
  • bioinformatics analysis
  • clinical evaluation