Interpreting change on the Symbol Digit Modalities Test in people with relapsing multiple sclerosis using the reliable change methodology.
Zachary L WeinstockSarah MorrowDevon S ConwayTom A FuchsCurtis WojcikMahmut UnverdiRobert ZivadinovBianca Weinstock-GuttmanGrant L IversonMichael DwyerRalph Hb BenedictPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)
This study illustrates the feasibility and usefulness of reliable change methodology for identifying statistically meaningful cognitive decline that could be implemented to identify change in individual patients, for both clinical management and clinical trial outcomes.
Keyphrases
- multiple sclerosis
- cognitive decline
- clinical trial
- end stage renal disease
- mild cognitive impairment
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- randomized controlled trial
- open label
- prognostic factors
- systemic lupus erythematosus
- metabolic syndrome
- study protocol
- patient reported outcomes
- patient reported
- rheumatoid arthritis