Adenocarcinoma of the stomach and esophagogastric junction with low DNA methylation show poor prognoses.

Masayuki UrabeKeisuke MatsusakaTetsuo UshikuMasaki FukuyoBahityar RahmutullaHiroharu YamashitaYasuyuki SetoMasashi FukayamaAtsushi Kaneda

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2022)

E-LME cases, newly confirmed in this study, form a unique subtype with poor prognosis that is not associated with inflammation-associated elevation of DNA methylation levels. LME could be acquired via chronic inflammation, regardless of the cause, and AEG might preferentially show HME.

Keyphrases

poor prognosis
dna methylation
long non coding rna
oxidative stress
genome wide
gene expression
squamous cell carcinoma
copy number
radiation therapy