Migraine susceptibility is modulated by food triggers and analgesic overuse via sulfotransferase inhibition.

Doga VuralliBurak ArslanElif TopaAndreia Lopes de MoraisOzlem GulbaharCenk AyataHayrunnisa Bolay Belen

Published in: The journal of headache and pain (2022)

Mefenamic acid and hesperidin have synergistic effect in modulating CSD susceptibility and pain behavior. Sulfotransferase inhibition may be the common mechanism by which food triggers and NSAIDs modulate migraine susceptibility. Further investigations regarding human provocation studies using hesperidin in migraine patients with medication overuse are needed.

Keyphrases

endothelial cells
neuropathic pain
chronic pain
healthcare
human health
signaling pathway
pain management
emergency department
risk assessment
spinal cord
climate change
pluripotent stem cells
drug induced
postoperative pain