PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model.

Xichun QinCaili JiaJingtian LiangJiali ChenXiucheng LiuZhixiang ChaoHao QinYanliang YuanZhiwei LiuZhongming ZhangHongyan DongHao Zhang

Published in: Respiratory research (2022)

PEDF can act as an anti-fibrotic factor, inhibit fibroblast activation by upregulating PPAR-γ activity and reduce BLM-induced pulmonary fibrosis in rats.

Keyphrases

pulmonary fibrosis
high glucose
drug induced
systemic sclerosis
insulin resistance
metabolic syndrome
type diabetes
fatty acid