The Two-Faced Role of crAssphage Subfamilies in Obesity and Metabolic Syndrome: Between Good and Evil.
Melany Cervantes-EcheverríaLuigui Gallardo-BecerraFernanda Cornejo-GranadosOchoa-Leyva AdrianPublished in: Genes (2023)
Viral metagenomic studies of the human gut microbiota have unraveled the differences in phage populations between health and disease, stimulating interest in phages' role on bacterial ecosystem regulation. CrAssphage is a common and abundant family in the gut virome across human populations. Therefore, we explored its role in obesity (O) and obesity with metabolic syndrome (OMS) in a children's cohort. We found a significantly decreased prevalence, diversity, and richness of the crAssphage Alpha subfamily in OMS mainly driven by a decrease in the Alpha_1 and Alpha_4 genera. On the contrary, there was a significant increase in the Beta subfamily in OMS, mainly driven by an increase in Beta_6. Additionally, an overabundance of the Delta_8 genus was observed in OMS. Notably, a decreased abundance of crAssphages was significantly correlated with the overabundance of Bacilli in the same group. The Bacilli class is a robust taxonomical biomarker of O and was also significantly abundant in our OMS cohort. Our results suggest that a loss of stability in the Alpha subfamily of crAssphages is associated with O and OMS. Contrary, an overabundance of the Delta subfamily was found in OMS. Our study advises the importance of considering the dual role (good and evil) of crAssphage subfamilies and their participation in conditions such as O, where we suggest that Alpha loss and Delta gain are associated with obese individuals.
Keyphrases
- metabolic syndrome
- insulin resistance
- weight loss
- endothelial cells
- type diabetes
- uric acid
- high fat diet induced
- weight gain
- adipose tissue
- gram negative
- cardiovascular risk factors
- public health
- induced pluripotent stem cells
- mental health
- bariatric surgery
- skeletal muscle
- young adults
- sars cov
- pluripotent stem cells
- physical activity
- body mass index
- pseudomonas aeruginosa
- risk assessment
- antibiotic resistance genes