Venetoclax: a real game changer in treatment of chronic lymphocytic leukemia.
Stefano MolicaPublished in: International journal of hematologic oncology (2020)
Venetoclax - a novel, orally bioavailable inhibitor of B-cell lymphoma-2 - has demonstrated substantial clinical activity in the treatment of chronic lymphocytic leukemia. Alone or in combination with other targeted agents, venetoclax results in high rate of durable responses and undetectable measurable residual disease. The peculiarity of venetoclax is that it allows for fixed durations of therapy of 12 months in the frontline and 24 months in the relapsed/refractory setting, with a favorable impact on compliance and pharmacoeconomics. This approach implies a change of therapeutic paradigm in chronic lymphocytic leukemia from continuous to time-fixed therapy. Nowadays, it remains challenging to identify patients suitable for the optimal approach. Clinical trials addressing the issue of continuous versus time-limited therapy are ongoing.
Keyphrases
- chronic lymphocytic leukemia
- clinical trial
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- acute lymphoblastic leukemia
- acute myeloid leukemia
- stem cells
- randomized controlled trial
- multiple myeloma
- mesenchymal stem cells
- bone marrow
- cancer therapy
- patient reported outcomes
- patient reported
- virtual reality
- phase iii