Expression of IL-17F is associated with non-pathogenic Th17 cells.

Florian WankeYilang TangKonrad GronkeSabrina KlebowSonja MoosJudith HauptmannArthi ShanmugavadivuTommy RegenIlgiz A MufazalovLauren A GabrielSonja ReißigAndreas DiefenbachFlorian C KurschusAri Waisman

Published in: Journal of molecular medicine (Berlin, Germany) (2018)

Naïve mice: CD4+ T cells and γδ T cells express IL-17A, and Tc17 cells express IL-17F. Gut ILC3 show differential expression of IL17A and F. Th17 differentiation with TGF-β1 induces IL-17A and F, whereas IL-1β induced cells expressing IL-17A. Th17 cells in EAE in CNS express IL-17A only. Gut Th17 cells induced by anti-CD3 express IL-17A and F together as skin γδ T cells of IMQ-treated mice.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
poor prognosis
type diabetes
metabolic syndrome
adipose tissue
insulin resistance
pi k akt
drug induced