Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry.
Francesc FormigaManuel Rubio-RivasJosé María Mora-LujánSamara Campos EscuderoRosa Fernandez Madera MartinezManuel Mendez-BailónPedro Durán-Del CampoAndrea Riaño PérezFrancisco-Javier García-SánchezJosé Nicolás Alcalá-PedrajasSergio Arnedo HernándezAlmudena Hernández MilianAna Latorre DíezRicardo Gil SánchezRamon BoixedaJulio VicenteBegoña CortesCarmen Mella PérezMaría Esther Guisado EsparteroJosé López CastroSantiago Rodríguez SuárezJose F VaronaRicardo Gomez-HuelgasJose Manuel Ramos-Rincónnull nullPublished in: Internal and emergency medicine (2021)
Acetylsalicylic acid (ASA) is widely used in the treatment and prevention of cardiovascular disorders. Our objective is to evaluate its possible protective role, not only in mortality but also in other aspects such as inflammation, symptomatic thrombosis, and intensive care unit (ICU) admission in hospitalized COVID-19 patients. We realized an observational retrospective cohort study of 20,641 patients with COVID-19 pneumonia collected and followed-up from Mar 1st, 2020 to May 1st, 2021, from the nationwide Spanish SEMI-COVID-19 Registry. Propensity score matching (PSM) was performed to determine whether treatment with ASA affected outcomes in COVID-19 patients. On hospital admission, 3291 (15.9%) patients were receiving ASA. After PSM, 3291 patients exposed to ASA and 2885 not-exposed patients were analyzed. In-hospital mortality was higher in the ASA group (30.4 vs. 16.9%, p < 0.001) in the global sample. After PSM, no differences were found between groups (30.4 vs. 30.3%, p = 0.938). There were no differences in inflammation, symptomatic thrombosis, or ICU admission. In conclusion, ASA intake is not associated with in-hospital mortality or any other health outcome evaluated after applying PSM analysis in a real-world large sample of hospitalized COVID-19 patients.
Keyphrases
- intensive care unit
- sars cov
- end stage renal disease
- emergency department
- newly diagnosed
- chronic kidney disease
- ejection fraction
- healthcare
- coronavirus disease
- prognostic factors
- oxidative stress
- pulmonary embolism
- public health
- body mass index
- machine learning
- cross sectional
- cardiovascular events
- weight gain
- big data
- respiratory syndrome coronavirus
- physical activity
- extracorporeal membrane oxygenation
- adverse drug