NLRP inflammasomes and induced skin inflammation, barrier recovery and extended skin hydration.

The role of the skin's innate immune response, controlled by NLRP inflammasomes, is beginning to be linked to numerous skin conditions including inflammaging. In this work, it was found that: (i) an in vitro assay could activate NHEKs to express NLRP inflammasome-induced ACasp-1 expression, (ii) Ingredient blends inhibited UVB and ATP-induced NLRP inflammasome-induced ACasp-1 expression, and (iii) skin barrier disruption improvements and extended skin hydration could be achieved with 3% of the polysaccharide blend.