Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration.
Aaron H WassermanRamachandran SaravananAitor AguirrePublished in: Cells (2020)
Cardiovascular disease (CVD) remains a leading cause of death globally. Understanding and characterizing the biochemical context of the cardiovascular system in health and disease is a necessary preliminary step for developing novel therapeutic strategies aimed at restoring cardiovascular function. Bioactive lipids are a class of dietary-dependent, chemically heterogeneous lipids with potent biological signaling functions. They have been intensively studied for their roles in immunity, inflammation, and reproduction, among others. Recent advances in liquid chromatography-mass spectrometry techniques have revealed a staggering number of novel bioactive lipids, most of them unknown or very poorly characterized in a biological context. Some of these new bioactive lipids play important roles in cardiovascular biology, including development, inflammation, regeneration, stem cell differentiation, and regulation of cell proliferation. Identifying the lipid signaling pathways underlying these effects and uncovering their novel biological functions could pave the way for new therapeutic strategies aimed at CVD and cardiovascular regeneration.
Keyphrases
- cardiovascular disease
- mass spectrometry
- stem cells
- liquid chromatography
- fatty acid
- cell proliferation
- oxidative stress
- type diabetes
- healthcare
- public health
- tandem mass spectrometry
- mental health
- single cell
- metabolic syndrome
- pi k akt
- gas chromatography
- high resolution
- cardiovascular events
- ms ms
- tissue engineering