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Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis.

Jenna M GregoryE ElliottK McDadeT BakS PalS ChandranS AbrahamsColin Smith
Published in: Neuropathology and applied neurobiology (2019)
Our data suggest that, in individuals with TDP-43 pathology, predominantly neuronal expression of clusterin in extra-motor brain regions may indicate a cell protective mechanism delaying clinical manifestations such as cognitive dysfunction.
Keyphrases
  • poor prognosis
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  • african american