Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids.

Qiwei YangMohamed AliLindsey S TreviñoAymara MasAyman Al-Hendy

Published in: Cellular and molecular life sciences : CMLS (2023)

Our studies identify epigenetic mechanisms of MLL1/DNA hypo-methylation-mediated MMSC reprogramming. EDC exposure epigenetically targets MMSCs and leads to persistent changes in the expression of a subset of ERGs, imparting a hormonal imprint on the ERGs, resulting in a "hyper-estrogenic" phenotype, and increasing the hormone-dependent risk of UFs.

Keyphrases

stem cells
dna methylation
poor prognosis
acute myeloid leukemia
circulating tumor
gene expression
cell free
genome wide
single molecule
binding protein
long non coding rna
protein protein
small molecule
mesenchymal stem cells