Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension.
Daniela FarkasA A Roger ThompsonAneel R BhagwaniSchuyler HultmanHyun JiNaveen KothaGrant FarrNadine D ArnoldAdam BraithwaiteHelen CasboltJennifer E ColeIan SabroeClaudia MonacoCarlyne D CoolElena A GoncharovaAllan LawrieA A Roger ThompsonPublished in: American journal of respiratory and critical care medicine (2019)
Our work identifies a novel role for TLR3 in PAH based on the findings that reduced expression of TLR3 contributes to endothelial apoptosis and pulmonary vascular remodeling.
Keyphrases
- toll like receptor
- pulmonary hypertension
- inflammatory response
- nuclear factor
- pulmonary artery
- poor prognosis
- immune response
- pulmonary arterial hypertension
- oxidative stress
- endoplasmic reticulum stress
- endothelial cells
- cell cycle arrest
- genome wide
- cell death
- binding protein
- polycyclic aromatic hydrocarbons
- signaling pathway