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Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension.

Daniela FarkasA A Roger ThompsonAneel R BhagwaniSchuyler HultmanHyun JiNaveen KothaGrant FarrNadine D ArnoldAdam BraithwaiteHelen CasboltJennifer E ColeIan SabroeClaudia MonacoCarlyne D CoolElena A GoncharovaAllan LawrieA A Roger Thompson
Published in: American journal of respiratory and critical care medicine (2019)
Our work identifies a novel role for TLR3 in PAH based on the findings that reduced expression of TLR3 contributes to endothelial apoptosis and pulmonary vascular remodeling.
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