Differential sensitivity of human islets from obese versus lean donors to chronic high glucose or palmitate.
Françoise CastexJeremy LeroyChristophe BrocaKarima MezghennaFlore DurantonVanessa LavallardFanny LebretonRené GrossAnne WojtusciszynAnne-Dominique LajoixPublished in: Journal of diabetes (2020)
Our data suggest that in addition to an increased sensitivity to glucose, islets from obese subjects can be considered as more resistant to glucose and fatty acid excursions and are thus valuable candidates for transplantation.
Keyphrases
- endothelial cells
- high glucose
- fatty acid
- adipose tissue
- weight loss
- metabolic syndrome
- blood glucose
- type diabetes
- obese patients
- electronic health record
- bariatric surgery
- big data
- induced pluripotent stem cells
- stem cells
- blood pressure
- insulin resistance
- kidney transplantation
- bone mineral density
- body composition
- skeletal muscle
- glycemic control
- postmenopausal women