TLR8 is expressed in monocytes in contrast to plasmacytoid dendritic cells and mediates aberrant IL-10 responses in patients with systemic sclerosis (SSc).

Christine EhlersThea ThieleHannah BiermannStephan TraidlLuzia BrunsAnnett ZieglerMatthias SchefzykLea M BartschUlrich KalinkeTorsten WitteTheresa Graalmann

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

TLR8 protein is not expressed in pDC of patients with SSc. Accordingly, they do not respond to TLR8 stimulation. In contrast, monocytes of patients with SSc respond to TLR8 stimulation with increased IL-10 responses. Therefore, TLR8 signaling in monocytes participates in SSc pathogenesis by conferring aberrant IL-10 expression.

Keyphrases

dendritic cells
immune response
toll like receptor
systemic sclerosis
inflammatory response
regulatory t cells
nuclear factor
interstitial lung disease
magnetic resonance
poor prognosis
magnetic resonance imaging
peripheral blood
contrast enhanced
protein protein
long non coding rna