Single-Cell RNA Sequencing Reveals Cellular Adaptation of Human Aortic Endothelial Cells to Antiproliferative Therapies Is Modulated by Flow-Induced Shear Stress.

Antonio G Salazar-Martín Aditya S Kalluri Martin A VillanuevaTravis K HughesMarc H Wadsworth Tyler T DaoMercedes BalcellsFarhad Rikhtegar Nezami Alex K Shalek Elazer R Edelman

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

We showed that flow shear stress modulates the cellular capacity of ECs to respond to paclitaxel and rapamycin administration, suggesting that while responding to different flow patterns, ECs experience an impairment in their transcriptional adaptation to other stimuli.

Keyphrases

endothelial cells
single cell
high glucose
rna seq
gene expression
transcription factor
aortic valve
left ventricular
high throughput
diabetic rats
pulmonary artery
coronary artery
atrial fibrillation
oxidative stress
heat shock