The influence of the gut microbiome on BCG-induced trained immunity.
Martin StražarVera P MouritsValerie A C M KoekenL Charlotte J de BreeSimone J C F M MoorlagLeo A B JoostenReinout van CrevelHera VlamakisMihai G NeteaRamnik J XavierPublished in: Genome biology (2021)
Variability in cytokine production after BCG vaccination is associated with the abundance of microbial genomes, which in turn affect or produce metabolites in circulation. Roseburia is found to alter both trained immune responses and phenylalanine metabolism, revealing microbes and microbial products that may alter BCG-induced immunity. Together, our findings contribute to the understanding of specific and trained immune responses after BCG vaccination.