Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells.

Haoxiao ZuoBing HanWilfred J PoppingaLennard RingnaldaLoes E M Kistemaker Andrew J Halayko Reinoud Gosens Viacheslav O Nikolaev Martina Christina Schmidt-Dengler

Published in: British journal of pharmacology (2018)

Exposure to CS, in vitro or in vivo, up-regulated expression and activity of both PDE3 and PDE4, which affected real-time cAMP dynamics. These mechanisms determine the availability of cAMP and can contribute to CS-induced pulmonary pathophysiology.

Keyphrases

binding protein
induced apoptosis
poor prognosis
protein kinase
pulmonary hypertension
cell cycle arrest
high glucose
transcription factor
diabetic rats
drug induced