Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.

Somaia ElsheikhIlias KouzoukakisCatherine FieldenWei LiShaimaa Elsaid LashinNadia KhairTeresa Pereira RaposoWakkas FadhilPhilip RudlandMohammed AleskandaranyPoulam PatelMohamed El-TananiMohammad Ilyas

Published in: Journal of clinical pathology (2020)

Ran is a poor prognostic marker in cutaneous MM. It upregulates expression of the oncogene c-Met and, possibly through this, it promotes cell motility which may in turn promote metastasis.

Keyphrases

single cell
cell therapy
poor prognosis
stem cells
tyrosine kinase
sensitive detection
cystic fibrosis
binding protein
quantum dots
candida albicans