SAR296968, a Novel Selective Na + /Ca 2+ Exchanger Inhibitor, Improves Ca 2+ Handling and Contractile Function in Human Atrial Cardiomyocytes.
Philipp HegnerMarzena DrzymalskiAlexander BiedermannBernadette MemmelMelanie DurczokMichael WesterBernhard FloerchingerZdenek ProvaznikChristof SchmidYork ZausigLars Siegfried MaierStefan WagnerPublished in: Biomedicines (2022)
The novel selective NCX-inhibitor SAR296968 inhibits atrial pro-arrhythmic activity and improves diastolic and contractile function in human atrial myocardium, which may have therapeutic implications, especially for treatment of HFpEF.