Immunological Interaction of HLA-DPB1 and Proteinase 3 in ANCA Vasculitis is Associated with Clinical Disease Activity.
Dhruti P ChenElizabeth A McInnisEveline Y WuKatherine G StemberSusan L HoganYichun HuCandace D HendersonLauren N BlazekSimon MallalEdita KarosieneBjoern PetersJohn SidneyEddie A JamesWilliam W KwokJ Charles JennetteDominic J CiavattaRonald J FalkMeghan E FreePublished in: Journal of the American Society of Nephrology : JASN (2022)
presented by HLA-DPB1*04:01. Although larger studies should validate these findings, the pathobiology may explain the observed increased risk of relapse in our cohort. Moreover, lack of HLA and autoantigen interaction observed during long-term remission signals immunologic nonresponsiveness.