TFE3-rearranged nonmelanotic renal PEComa: a case series expanding their phenotypic and fusion landscape.

Abbas Agaimy Andres Martin Acosta Liang Cheng Katrina M Collins Eddie FridmanChristoph SchubartSean R WilliamsonArndt HartmannKiril Trpkov

Published in: Histopathology (2024)

This study highlights the morphologic and genetic diversity of TFE3-rearranged primary renal PEComas and underlines the value of surrogate TFE3 immunohistochemistry in identifying them. The lack of PAX8 and keratin expression represents the mainstay for distinguishing these tumours from MiTF-associated renal cell carcinomas. In addition, we report rare (ZC3H4, RBMX) and novel (MED15) TFE3 fusion partners in PEComa.

Keyphrases

genetic diversity
single cell
poor prognosis
cell therapy
binding protein
mesenchymal stem cells
long non coding rna
hiv infected