Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review.
Mahnaz PoorhassanMorteza GholaminejhadHoussein AhmadiLeila MehboudiMahdis Chahar KamehMaryam PiraniGholamreza HassanzadehPublished in: Journal of lasers in medical sciences (2022)
About 50% of infertility problems are related to male factors and reduced sperm motility. The important factor that affects the structure and function of sperm is reactive oxygen species (ROS), and over-concentration of ROS reduces the quality and motility of sperm. Photobiomodulation therapy (PBMT) using red to near-infrared (NIR) light is useful in oxidative stress restoration. It plays a therapeutic role in disorders such as asthenospermia, oligospermia cases, and cryopreserved sperm. It also enhances the metabolic capacity of sperm and increases the low-level and non-harmful intracellular content of Ca 2+ , nitric oxide (NO), and ROS in the stressed cells. Likewise, it modulates survival intracellular pathways and maintains the motility, viability, DNA, and acrosome integrity of sperm. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of semen PBMT.
Keyphrases
- reactive oxygen species
- nitric oxide
- biofilm formation
- dna damage
- oxidative stress
- cell death
- induced apoptosis
- hydrogen peroxide
- mesenchymal stem cells
- type diabetes
- staphylococcus aureus
- pseudomonas aeruginosa
- cell cycle arrest
- quality improvement
- systematic review
- escherichia coli
- randomized controlled trial
- skeletal muscle
- fluorescence imaging
- umbilical cord
- circulating tumor cells
- wound healing
- adipose tissue
- metabolic syndrome
- nitric oxide synthase
- ischemia reperfusion injury