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Constructing germline research cohorts from the discarded reads of clinical tumor sequences.

Alexander GusevStefan GrohaKodi TaraszkaYevgeniy R SemenovNoah Zaitlen
Published in: Genome medicine (2021)
We conclude that targeted tumor sequencing can be leveraged to build rich germline research cohorts from existing data and make our analysis pipeline publicly available to facilitate this effort.
Keyphrases
  • dna repair
  • electronic health record
  • single cell
  • cancer therapy
  • big data
  • machine learning
  • oxidative stress
  • artificial intelligence