Alexander Gusev

ORCID

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 67

Top Venues

Nature medicine

Nature communications

Nature genetics

Nucleic acids research

Dana Farber Cancer Institute

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Dana Farber Cancer Institute Jan 1o 2017

United States

Member of Faculty :: Medical Oncology

Publications

Kenneth L Kehl, Hajime Uno, Alexander Gusev, Stefan Groha, Samantha Brown, Jessica A Lavery, Deborah Schrag, Katherine S Panageas
Elucidating Analytic Bias Due to Informative Cohort Entry in Cancer Clinico-genomic Datasets. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 32 (3) (2023)
Kenneth L Kehl, Hajime Uno, Alexander Gusev, Stefan Groha, Samantha Brown, Jessica A Lavery, Deborah Schrag, Katherine S Panageas
Elucidating Analytic Bias Due to Informative Cohort Entry in Cancer Clinico-genomic Datasets. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 32 (3) (2023)
Amin H Nassar, Sarah Abou Alaiwi, Sylvan C Baca, Elio Adib, Rosario I Corona, Ji-Heui Seo, Marcos A S Fonseca, Sándor Spisák, Talal El Zarif, Viktoria Tisza, David A Braun, Heng Du, Monica He, Abdallah Flaifel, Michel Alchoueiry, Thomas Denize, Sayed G Matar, Andres Acosta, Sachet A Shukla, Yue Hou, John Steinharter, Gabrielle Bouchard, Jacob E Berchuck, Edward O'Connor, Connor Bell, Pier Vitale Nuzzo, Gwo-Shu Mary Lee, Sabina Signoretti, Michelle S Hirsch, Mark Pomerantz, Elizabeth P Henske, Alexander Gusev, Kate Lawrenson, Toni K Choueiri, David J Kwiatkowski, Matthew L Freedman
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma. Nature communications 14 (1) (2023)
Alexander Gusev, Intae Moon, Jaclyn LoPiccolo, Sylvan Baca, Lynette M Sholl, Kenneth L Kehl, Michael Hassett, David R Liu, Deborah Schrag
Utilizing Electronic Health Records (EHR) and Tumor Panel Sequencing to Demystify Prognosis of Cancer of Unknown Primary (CUP) patients. Research square (2023)
Kenneth L Kehl, Hajime Uno, Alexander Gusev, Stefan Groha, Samantha Brown, Jessica A Lavery, Deborah Schrag, Katherine S Panageas
Elucidating analytic bias due to informative cohort entry in cancer clinico-genomic datasets. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2023)
Sándor Spisák, Viktoria Tisza, Pier Vitale Nuzzo, Ji-Heui Seo, Balint Pataki, Dezső Ribli, Zsofia Sztupinszki, Connor Bell, Mersedeh Rohanizadegan, David R Stillman, Sarah Abou Alaiwi, Alan H Bartels, Marton Papp, Anamay Shetty, Forough Abbasi, Xianzhi Lin, Kate Lawrenson, Simon A Gayther, Mark Pomerantz, Sylvan Baca, Norbert Solymosi, Istvan Csabai, Zoltan Szallasi, Alexander Gusev, Matthew L Freedman
Author Correction: A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus. Nature communications 14 (1) (2023)
Tunc Morova, Yi Ding, Chia-Chi F Huang, Funda Sar, Tommer Schwarz, Claudia Giambartolomei, Sylvan C Baca, Dennis Grishin, Faraz Hach, Alexander Gusev, Matthew L Freedman, Bogdan Pasaniuc, Nathan A Lack
Optimized high-throughput screening of non-coding variants identified from genome-wide association studies. Nucleic acids research 51 (3) (2023)
Kenneth L Kehl, Hajime Uno, Alexander Gusev, Stefan Groha, Samantha Brown, Jessica A Lavery, Deborah Schrag, Katherine S Panageas
Elucidating Analytic Bias Due to Informative Cohort Entry in Cancer Clinico-genomic Datasets. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 32 (3) (2023)
Tunc Morova, Yi Ding, Chia-Chi F Huang, Funda Sar, Tommer Schwarz, Claudia Giambartolomei, Sylvan C Baca, Dennis Grishin, Faraz Hach, Alexander Gusev, Matthew L Freedman, Bogdan Pasaniuc, Nathan A Lack
Optimized high-throughput screening of non-coding variants identified from genome-wide association studies. Nucleic acids research 51 (3) (2023)
Alexander Gusev, Intae Moon, Jaclyn LoPiccolo, Sylvan Baca, Lynette M Sholl, Kenneth L Kehl, Michael Hassett, David R Liu, Deborah Schrag
Utilizing Electronic Health Records (EHR) and Tumor Panel Sequencing to Demystify Prognosis of Cancer of Unknown Primary (CUP) patients. Research square (2023)
Amin H Nassar, Sarah Abou Alaiwi, Sylvan C Baca, Elio Adib, Rosario I Corona, Ji-Heui Seo, Marcos A S Fonseca, Sándor Spisák, Talal El Zarif, Viktoria Tisza, David A Braun, Heng Du, Monica He, Abdallah Flaifel, Michel Alchoueiry, Thomas Denize, Sayed G Matar, Andres Acosta, Sachet A Shukla, Yue Hou, John Steinharter, Gabrielle Bouchard, Jacob E Berchuck, Edward O'Connor, Connor Bell, Pier Vitale Nuzzo, Gwo-Shu Mary Lee, Sabina Signoretti, Michelle S Hirsch, Mark Pomerantz, Elizabeth P Henske, Alexander Gusev, Kate Lawrenson, Toni K Choueiri, David J Kwiatkowski, Matthew L Freedman
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma. Nature communications 14 (1) (2023)
Yuxi Liu, Alexander Gusev, Peter Kraft
Germline cancer gene expression quantitative trait loci are associated with local and global tumor mutations. Cancer research (2023)
Amin H Nassar, Sarah Abou Alaiwi, Sylvan C Baca, Elio Adib, Rosario I Corona, Ji-Heui Seo, Marcos A S Fonseca, Sándor Spisák, Talal El Zarif, Viktoria Tisza, David A Braun, Heng Du, Monica He, Abdallah Flaifel, Michel Alchoueiry, Thomas Denize, Sayed G Matar, Andres Acosta, Sachet A Shukla, Yue Hou, John Steinharter, Gabrielle Bouchard, Jacob E Berchuck, Edward O'Connor, Connor Bell, Pier Vitale Nuzzo, Gwo-Shu Mary Lee, Sabina Signoretti, Michelle S Hirsch, Mark Pomerantz, Elizabeth P Henske, Alexander Gusev, Kate Lawrenson, Toni K Choueiri, David J Kwiatkowski, Matthew L Freedman
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma. Nature communications 14 (1) (2023)
Sándor Spisák, Viktoria Tisza, Pier Vitale Nuzzo, Ji-Heui Seo, Balint Pataki, Dezső Ribli, Zsofia Sztupinszki, Connor Bell, Mersedeh Rohanizadegan, David R Stillman, Sarah Abou Alaiwi, Alan B Bartels, Marton Papp, Anamay Shetty, Forough Abbasi, Xianzhi Lin, Kate Lawrenson, Simon A Gayther, Mark Pomerantz, Sylvan Baca, Norbert Solymosi, Istvan Csabai, Zoltan Szallasi, Alexander Gusev, Matthew L Freedman
A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus. Nature communications 14 (1) (2023)
Alexander Gusev, Intae Moon, Jaclyn LoPiccolo, Sylvan Baca, Lynette M Sholl, Kenneth L Kehl, Michael Hassett, David R Liu, Deborah Schrag
Utilizing Electronic Health Records (EHR) and Tumor Panel Sequencing to Demystify Prognosis of Cancer of Unknown Primary (CUP) patients. Research square (2023)
Yuxi Liu, Alexander Gusev, Peter Kraft
Germline cancer gene expression quantitative trait loci are associated with local and global tumor mutations. Cancer research (2023)
Douglas W Yao, Loic Binan, Jon Bezney, Brooke Simonton, Jahanara Freedman, Chris J Frangieh, Kushal K Dey, Kathryn Geiger-Schuller, Basak Eraslan, Alexander Gusev, Aviv Regev, Brian Cleary
Scalable genetic screening for regulatory circuits using compressed Perturb-seq. Nature biotechnology (2023)
Intae Moon, Jaclyn LoPiccolo, Sylvan C Baca, Lynette M Sholl, Kenneth L Kehl, Michael J Hassett, David R Liu, Deborah Schrag, Alexander Gusev
Utilizing Electronic Health Records (EHR) and Tumor Panel Sequencing to Demystify Prognosis of Cancer of Unknown Primary (CUP) patients. Research square (2023)
Yuxi Liu, Alexander Gusev, Peter Kraft
Germline cancer gene expression quantitative trait loci are associated with local and global tumor mutations. Cancer research (2023)
Amin H Nassar, Sarah Abou Alaiwi, Sylvan C Baca, Elio Adib, Rosario I Corona, Ji-Heui Seo, Marcos A S Fonseca, Sándor Spisák, Talal El Zarif, Viktoria Tisza, David A Braun, Heng Du, Monica He, Abdallah Flaifel, Michel Alchoueiry, Thomas Denize, Sayed G Matar, Andres Acosta, Sachet A Shukla, Yue Hou, John Steinharter, Gabrielle Bouchard, Jacob E Berchuck, Edward O'Connor, Connor Bell, Pier Vitale Nuzzo, Gwo-Shu Mary Lee, Sabina Signoretti, Michelle S Hirsch, Mark Pomerantz, Elizabeth P Henske, Alexander Gusev, Kate Lawrenson, Toni K Choueiri, David J Kwiatkowski, Matthew L Freedman
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma. Nature communications 14 (1) (2023)
Intae Moon, Jaclyn LoPiccolo, Sylvan C Baca, Lynette M Sholl, Kenneth L Kehl, Michael J Hassett, David R Liu, Deborah Schrag, Alexander Gusev
Publisher Correction: Machine learning for genetics-based classification and treatment response prediction in cancer of unknown primary. Nature medicine (2023)
Alexander Gusev
Germline mechanisms of immunotherapy toxicities in the era of genome-wide association studies. Immunological reviews (2023)
Yuxi Liu, Alexander Gusev, Peter Kraft
Germline cancer gene expression quantitative trait loci are associated with local and global tumor mutations. Cancer research (2023)
Yixuan He, David C Qian, James A Diao, Michael H Cho, Edwin K Silverman, Alexander Gusev, Arjun K Manrai, Alicia R Martin, Chirag J Patel
Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors. medRxiv : the preprint server for health sciences (2023)
Tunc Morova, Yi Ding, Chia-Chi F Huang, Funda Sar, Tommer Schwarz, Claudia Giambartolomei, Sylvan C Baca, Dennis Grishin, Faraz Hach, Alexander Gusev, Matthew L Freedman, Bogdan Pasaniuc, Nathan A Lack
Optimized high-throughput screening of non-coding variants identified from genome-wide association studies. Nucleic acids research 51 (3) (2023)
Intae Moon, Jaclyn LoPiccolo, Sylvan C Baca, Lynette M Sholl, Kenneth L Kehl, Michael J Hassett, David R Liu, Deborah Schrag, Alexander Gusev
Machine learning for genetics-based classification and treatment response prediction in cancer of unknown primary. Nature medicine (2023)
Timothy R Rebbeck, Rohini Janivara, Wenlong Chen, Ujani Hazra, Shakuntala Baichoo, Ilir Agalliu, Paidamoyo Kachambwa, Corinne Simonti, Lyda Brown, Saanika Tambe, Michelle Kim, Maxine Harlemon, Mohamed Jalloh, Dillon Muzondiwa, Daphne Naidoo, Olabode Ajayi, Nana Snyper, Lamine Niang, Halimatou Diop, Medina Ndoye, James Edward Mensah, Afua O D Abrahams, Richard Biritwum, Andrew Adjei, Akindele O Adebiyi, Olayiwola Shittu, Olufemi Ogunbiyi, Sikiru Adebayo, Maxwell Nwegbu, Hafees Ajibola, Olabode Oluwole, Mustapha Jamda, Audrey Pentz, Christopher A Haiman, Petrus Spies, Andre Van der Merwe, Michael Cook, Stephen J Chanock, Sonja I Berndt, Stephen Watya, Alex Lubwama, Mazvita Muchengeti, Sean Doherty, Natalie Smyth, David Lounsbury, Brian Fortier, Thomas Rohan, Judith Jacobson, Alfred Neugut, Ann Hsing, Alexander Gusev, Oseremen Aisuodionoe-Shadrach, Maureen Joffe, Ben Adusei, Serigne Gueye, Pedro Fernandez, Jo McBride, Caroline Andrews, Lindsay Petersen, Joseph Lachance
Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan Africa. Research square (2023)
Amin H Nassar, Sarah Abou Alaiwi, Sylvan C Baca, Elio Adib, Rosario I Corona, Ji-Heui Seo, Marcos A S Fonseca, Sándor Spisák, Talal El Zarif, Viktoria Tisza, David A Braun, Heng Du, Monica He, Abdallah Flaifel, Michel Alchoueiry, Thomas Denize, Sayed G Matar, Andres Acosta, Sachet A Shukla, Yue Hou, John Steinharter, Gabrielle Bouchard, Jacob E Berchuck, Edward O'Connor, Connor Bell, Pier Vitale Nuzzo, Gwo-Shu Mary Lee, Sabina Signoretti, Michelle S Hirsch, Mark Pomerantz, Elizabeth P Henske, Alexander Gusev, Kate Lawrenson, Toni K Choueiri, David J Kwiatkowski, Matthew L Freedman
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma. Nature communications 14 (1) (2023)
Kenneth L Kehl, Hajime Uno, Alexander Gusev, Stefan Groha, Samantha Brown, Jessica A Lavery, Deborah Schrag, Katherine S Panageas
Elucidating Analytic Bias Due to Informative Cohort Entry in Cancer Clinico-genomic Datasets. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 32 (3) (2023)
Tunc Morova, Yi Ding, Chia-Chi F Huang, Funda Sar, Tommer Schwarz, Claudia Giambartolomei, Sylvan C Baca, Dennis Grishin, Faraz Hach, Alexander Gusev, Matthew L Freedman, Bogdan Pasaniuc, Nathan A Lack
Optimized high-throughput screening of non-coding variants identified from genome-wide association studies. Nucleic acids research (2022)
Chelsea A Taylor, Robert A Watson, Orion Tong, Weiyu Ye, Isar Nassiri, James J Gilchrist, Alba Verge de Los Aires, Piyush Kumar Sharma, Surya Koturan, Rosalin A Cooper, Victoria K Woodcock, Elsita Jungkurth, Brian Shine, Nicholas Coupe, Miranda J Payne, David N Church, Vivek Naranbhai, Stefan Groha, Paul Emery, Kulveer Mankia, Matthew L Freedman, Toni K Choueiri, Mark Ross Middleton, Alexander Gusev, Benjamin P Fairfax
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nature medicine (2022)
Chelsea A Taylor, Robert A Watson, Orion Tong, Weiyu Ye, Isar Nassiri, James J Gilchrist, Alba Verge de Los Aires, Piyush Kumar Sharma, Surya Koturan, Rosalin A Cooper, Victoria K Woodcock, Elsita Jungkurth, Brian Shine, Nicholas Coupe, Miranda J Payne, David N Church, Vivek Naranbhai, Stefan Groha, Paul Emery, Kulveer Mankia, Matthew L Freedman, Toni K Choueiri, Mark Ross Middleton, Alexander Gusev, Benjamin P Fairfax
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nature medicine 28 (12) (2022)
Chelsea A Taylor, Robert A Watson, Orion Tong, Weiyu Ye, Isar Nassiri, James J Gilchrist, Alba Verge de Los Aires, Piyush Kumar Sharma, Surya Koturan, Rosalin A Cooper, Victoria K Woodcock, Elsita Jungkurth, Brian Shine, Nicholas Coupe, Miranda J Payne, David N Church, Vivek Naranbhai, Stefan Groha, Paul Emery, Kulveer Mankia, Matthew L Freedman, Toni K Choueiri, Mark Ross Middleton, Alexander Gusev, Benjamin P Fairfax
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nature medicine 28 (12) (2022)
Dennis Grishin, Alexander Gusev
Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms. Nature genetics 54 (6) (2022)
Chelsea A Taylor, Robert A Watson, Orion Tong, Weiyu Ye, Isar Nassiri, James J Gilchrist, Alba Verge de Los Aires, Piyush Kumar Sharma, Surya Koturan, Rosalin A Cooper, Victoria K Woodcock, Elsita Jungkurth, Brian Shine, Nicholas Coupe, Miranda J Payne, David N Church, Vivek Naranbhai, Stefan Groha, Paul Emery, Kulveer Mankia, Matthew L Freedman, Toni K Choueiri, Mark Ross Middleton, Alexander Gusev, Benjamin P Fairfax
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nature medicine 28 (12) (2022)
Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H Nassar, Ziad Bakouny, Talal El Zarif, Renee Maria Saliby, Guihong Wan, Ahmad Rajeh, Elio Adib, Pier Vitale Nuzzo, Andrew L Schmidt, Chris Labaki, Biagio Ricciuti, Joao Victor Alessi, David A Braun, Sachet A Shukla, Tanya E Keenan, Eliezer Van Allen, Mark M Awad, Michael Manos, Osama Rahma, Leyre Zubiri, Alexandra-Chloe Villani, Benjamin P Fairfax, Christian Hammer, Zia Khan, Kerry Reynolds, Yevgeniy R Semenov, Deborah Schrag, Kenneth L Kehl, Matthew L Freedman, Toni K Choueiri, Alexander Gusev
Germline variants associated with toxicity to immune checkpoint blockade. Nature medicine 28 (12) (2022)
Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H Nassar, Ziad Bakouny, Talal El Zarif, Renee Maria Saliby, Guihong Wan, Ahmad Rajeh, Elio Adib, Pier Vitale Nuzzo, Andrew L Schmidt, Chris Labaki, Biagio Ricciuti, Joao Victor Alessi, David A Braun, Sachet A Shukla, Tanya E Keenan, Eliezer Van Allen, Mark M Awad, Michael Manos, Osama Rahma, Leyre Zubiri, Alexandra-Chloe Villani, Benjamin P Fairfax, Christian Hammer, Zia Khan, Kerry Reynolds, Yevgeniy R Semenov, Deborah Schrag, Kenneth L Kehl, Matthew L Freedman, Toni K Choueiri, Alexander Gusev
Germline variants associated with toxicity to immune checkpoint blockade. Nature medicine 28 (12) (2022)
Chelsea A Taylor, Robert A Watson, Orion Tong, Weiyu Ye, Isar Nassiri, James J Gilchrist, Alba Verge de Los Aires, Piyush Kumar Sharma, Surya Koturan, Rosalin A Cooper, Victoria K Woodcock, Elsita Jungkurth, Brian Shine, Nicholas Coupe, Miranda J Payne, David N Church, Vivek Naranbhai, Stefan Groha, Paul Emery, Kulveer Mankia, Matthew L Freedman, Toni K Choueiri, Mark Ross Middleton, Alexander Gusev, Benjamin P Fairfax
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nature medicine 28 (12) (2022)
Tunc Morova, Yi Ding, Chia-Chi F Huang, Funda Sar, Tommer Schwarz, Claudia Giambartolomei, Sylvan C Baca, Dennis Grishin, Faraz Hach, Alexander Gusev, Matthew L Freedman, Bogdan Pasaniuc, Nathan A Lack
Optimized high-throughput screening of non-coding variants identified from genome-wide association studies. Nucleic acids research (2022)
Daniel Munro, Tengfei Wang, Apurva S Chitre, Oksana Polesskaya, Nava Ehsan, Jianjun Gao, Alexander Gusev, Leah C Solberg Woods, Laura M Saba, Hao Chen, Abraham A Palmer, Pejman Mohammadi
The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats. Nucleic acids research 50 (19) (2022)
Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H Nassar, Ziad Bakouny, Talal El Zarif, Renee Maria Saliby, Guihong Wan, Ahmad Rajeh, Elio Adib, Pier Vitale Nuzzo, Andrew L Schmidt, Chris Labaki, Biagio Ricciuti, Joao Victor Alessi, David A Braun, Sachet A Shukla, Tanya E Keenan, Eliezer Van Allen, Mark M Awad, Michael Manos, Osama Rahma, Leyre Zubiri, Alexandra-Chloe Villani, Benjamin P Fairfax, Christian Hammer, Zia Khan, Kerry Reynolds, Yevgeniy R Semenov, Deborah Schrag, Kenneth L Kehl, Matthew L Freedman, Toni K Choueiri, Alexander Gusev
Germline variants associated with toxicity to immune checkpoint blockade. Nature medicine 28 (12) (2022)
Chelsea A Taylor, Robert A Watson, Orion Tong, Weiyu Ye, Isar Nassiri, James J Gilchrist, Alba Verge de Los Aires, Piyush Kumar Sharma, Surya Koturan, Rosalin A Cooper, Victoria K Woodcock, Elsita Jungkurth, Brian Shine, Nicholas Coupe, Miranda J Payne, David N Church, Vivek Naranbhai, Stefan Groha, Paul Emery, Kulveer Mankia, Matthew L Freedman, Toni K Choueiri, Mark Ross Middleton, Alexander Gusev, Benjamin P Fairfax
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nature medicine 28 (12) (2022)
Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H Nassar, Ziad Bakouny, Talal El Zarif, Renee Maria Saliby, Guihong Wan, Ahmad Rajeh, Elio Adib, Pier Vitale Nuzzo, Andrew L Schmidt, Chris Labaki, Biagio Ricciuti, Joao Victor Alessi, David A Braun, Sachet A Shukla, Tanya E Keenan, Eliezer Van Allen, Mark M Awad, Michael Manos, Osama Rahma, Leyre Zubiri, Alexandra-Chloe Villani, Benjamin P Fairfax, Christian Hammer, Zia Khan, Kerry Reynolds, Yevgeniy R Semenov, Deborah Schrag, Kenneth L Kehl, Matthew L Freedman, Toni K Choueiri, Alexander Gusev
Germline variants associated with toxicity to immune checkpoint blockade. Nature medicine 28 (12) (2022)
Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H Nassar, Ziad Bakouny, Talal El Zarif, Renee Maria Saliby, Guihong Wan, Ahmad Rajeh, Elio Adib, Pier Vitale Nuzzo, Andrew L Schmidt, Chris Labaki, Biagio Ricciuti, Joao Victor Alessi, David A Braun, Sachet A Shukla, Tanya E Keenan, Eliezer Van Allen, Mark M Awad, Michael Manos, Osama Rahma, Leyre Zubiri, Alexandra-Chloe Villani, Benjamin P Fairfax, Christian Hammer, Zia Khan, Kerry Reynolds, Yevgeniy R Semenov, Deborah Schrag, Kenneth L Kehl, Matthew L Freedman, Toni K Choueiri, Alexander Gusev
Germline variants associated with toxicity to immune checkpoint blockade. Nature medicine (2022)
Chelsea A Taylor, Robert A Watson, Orion Tong, Weiyu Ye, Isar Nassiri, James J Gilchrist, Alba Verge de Los Aires, Piyush Kumar Sharma, Surya Koturan, Rosalin A Cooper, Victoria K Woodcock, Elsita Jungkurth, Brian Shine, Nicholas Coupe, Miranda J Payne, David N Church, Vivek Naranbhai, Stefan Groha, Paul Emery, Kulveer Mankia, Matthew L Freedman, Toni K Choueiri, Mark Ross Middleton, Alexander Gusev, Benjamin P Fairfax
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nature medicine 28 (12) (2022)
Sylvan C Baca, Cassandra Singler, Soumya Zacharia, Ji-Heui Seo, Tunc Morova, Faraz Hach, Yi Ding, Tommer Schwarz, Chia-Chi Flora Huang, Jacob Anderson, André P Fay, Cynthia Kalita, Stefan Groha, Mark M Pomerantz, Victoria Wang, Simon Linder, Christopher J Sweeney, Wilbert Zwart, Nathan A Lack, Bogdan Pasaniuc, David Y Takeda, Alexander Gusev, Matthew L Freedman
Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation. Nature genetics 54 (9) (2022)
Sophia C Kamran, Jamie Xie, Alexander T M Cheung, Mnaya Y Mavura, Hanbing Song, Elina L Palapattu, Joanna Madej, Alexander Gusev, Eliezer Van Allen, Franklin W Huang
Tumor Mutations Across Racial Groups in a Real-World Data Registry. JCO precision oncology 5 (2022)
Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H Nassar, Ziad Bakouny, Talal El Zarif, Renee Maria Saliby, Guihong Wan, Ahmad Rajeh, Elio Adib, Pier Vitale Nuzzo, Andrew L Schmidt, Chris Labaki, Biagio Ricciuti, Joao Victor Alessi, David A Braun, Sachet A Shukla, Tanya E Keenan, Eliezer Van Allen, Mark M Awad, Michael Manos, Osama Rahma, Leyre Zubiri, Alexandra-Chloe Villani, Benjamin P Fairfax, Christian Hammer, Zia Khan, Kerry Reynolds, Yevgeniy R Semenov, Deborah Schrag, Kenneth L Kehl, Matthew L Freedman, Toni K Choueiri, Alexander Gusev
Germline variants associated with toxicity to immune checkpoint blockade. Nature medicine 28 (12) (2022)
Alexander Gusev, Stefan Groha, Kodi Taraszka, Yevgeniy R Semenov, Noah Zaitlen
Constructing germline research cohorts from the discarded reads of clinical tumor sequences. Genome medicine 13 (1) (2021)
Helian Feng, Nicholas Mancuso, Alexander Gusev, Arunabha Majumdar, Megan Major, Bogdan Pasaniuc, Peter Kraft
Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies. PLoS genetics 17 (4) (2021)
Kenneth L Kehl, Stefan Groha, Eva M Lepisto, Haitham A Elmarakeby, James R Lindsay, Alexander Gusev, Eliezer M Van Allen, Michael J Hassett, Deborah Schrag
Clinical Inflection Point Detection on the Basis of EHR Data to Identify Clinical Trial-Ready Patients With Cancer. JCO clinical cancer informatics 5 (2021)
Nahed Jalloul, Israel Gomy, Samantha Stokes, Alexander Gusev, Bruce E Johnson, Neal I Lindeman, Laura Macconaill, Shridar Ganesan, Judy E Garber, Hossein Khiabanian
Germline Testing Data Validate Inferences of Mutational Status for Variants Detected From Tumor-Only Sequencing. JCO precision oncology 5 (2021)
Jessica Reddy, Marcos A S Fonseca, Rosario I Corona, Robbin Nameki, Felipe Segato Dezem, Isaac A Klein, Heidi Chang, Daniele Chaves-Moreira, Lena K Afeyan, Tathiane Maistro Malta, Xianzhi Lin, Forough Abbasi, Alba Font-Tello, Thais Sabedot, Paloma Cejas, Norma Rodríguez-Malavé, Ji-Heui Seo, De-Chen Lin, Ursula Matulonis, Beth Y Karlan, Simon A Gayther, Bogdan Pasaniuc, Alexander Gusev, Houtan Noushmehr, Henry W Long, Matthew L Freedman, Ronny Drapkin, Richard A Young, Brian J Abraham, Kate Lawrenson
Predicting master transcription factors from pan-cancer expression data. Science advances 7 (48) (2021)
Kenneth L Kehl, Wenxin Xu, Alexander Gusev, Ziad Bakouny, Toni K Choueiri, Irbaz Bin Riaz, Haitham Elmarakeby, Eliezer Van Allen, Deborah Schrag
Artificial intelligence-aided clinical annotation of a large multi-cancer genomic dataset. Nature communications 12 (1) (2021)
Douglas W Yao, Luke O' Connor, Alkes L Price, Alexander Gusev
Quantifying genetic effects on disease mediated by assayed gene expression levels. Nature genetics 52 (6) (2020)
Rosario I Corona, Ji-Heui Seo, Xianzhi Lin, Dennis J Hazelett, Jessica Reddy, Marcos A S Fonseca, Forough Abassi, Yvonne G Lin, Paulette Y Mhawech-Fauceglia, Sohrab P Shah, David G Huntsman, Alexander Gusev, Beth Y Karlan, Benjamin P Berman, Matthew L Freedman, Simon A Gayther, Kate Lawrenson
Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer. Nature communications 11 (1) (2020)
Mark M Pomerantz, Xintao Qiu, Yanyun Zhu, David Y Takeda, Wenting Pan, Sylvan C Baca, Alexander Gusev, Keegan D Korthauer, Tesa M Severson, Gavin Ha, Srinivas R Viswanathan, Ji-Heui Seo, Holly M Nguyen, Baohui Zhang, Bogdan Pasaniuc, Claudia Giambartolomei, Sarah A Alaiwi, Connor A Bell, Edward P O'Connor, Matthew S Chabot, David R Stillman, Rosina Lis, Alba Font-Tello, Lewyn Li, Paloma Cejas, Andries M Bergman, Joyce Sanders, Henk G van der Poel, Simon A Gayther, Kate Lawrenson, Marcos A S Fonseca, Jessica Reddy, Rosario I Corona, Gleb Martovetsky, Brian Egan, Toni K Choueiri, Leigh Ellis, Isla P Garraway, Gwo-Shu Mary Lee, Eva Corey, Henry W Long, Wilbert Zwart, Matthew L Freedman
Prostate cancer reactivates developmental epigenomic programs during metastatic progression. Nature genetics 52 (8) (2020)
Juba Nait Saada, Georgios Kalantzis, Derek Shyr, Fergus Cooper, Martin J Robinson, Alexander Gusev, Pier Francesco Palamara
Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations. Nature communications 11 (1) (2020)
Nicholas Mancuso, Simon Gayther, Alexander Gusev, Quan Long, Kathryn L Penney, null null, Zsofia Kote-Jarai, Rosalind A Eeles, Matthew Freedman, Christopher Haiman, Bogdan Pasaniuc
Author Correction: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions. Nature communications 10 (1) (2019)
Alexander Gusev, Kate Lawrenson, Xianzhi Lin, Paulo C Lyra, Siddhartha Kar, Kevin C Vavra, Felipe Segato, Marcos A S Fonseca, Janet M Lee, Tanya Pejovic, Gang Liu, null null, Beth Y Karlan, Matthew L Freedman, Houtan Noushmehr, Alvaro N A Monteiro, Paul D P Pharoah, Bogdan Pasaniuc, Simon A Gayther
A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants. Nature genetics 51 (5) (2019)
Nicholas Mancuso, Malika K Freund, Ruth Johnson, Huwenbo Shi, Gleb Kichaev, Alexander Gusev, Bogdan Pasaniuc
Probabilistic fine-mapping of transcriptome-wide association studies. Nature genetics 51 (4) (2019)
Yakir A Reshef, Hilary K Finucane, David R Kelley, Alexander Gusev, Dylan Kotliar, Jacob C Ulirsch, Farhad Hormozdiari, Joseph Nasser, Luke O' Connor, Bryce van de Geijn, Po-Ru Loh, Sharon R Grossman, Gaurav Bhatia, Steven Gazal, Pier Francesco Palamara, Luca Pinello, Nick Patterson, Ryan P Adams, Alkes L Price
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk. Nature genetics 50 (10) (2018)
Hilary K Finucane, Yakir A Reshef, Verneri Anttila, Kamil Slowikowski, Alexander Gusev, Andrea Byrnes, Steven Gazal, Po-Ru Loh, Caleb Lareau, Noam Shoresh, Giulio Genovese, Arpiar Saunders, Evan Macosko, Samuela Pollack, null null, John R B Perry, Jason D Buenrostro, Bradley E Bernstein, Soumya Raychaudhuri, Steven McCarroll, Benjamin M Neale, Alkes L Price
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nature genetics 50 (4) (2018)
Alexander Gusev, Nicholas Mancuso, Hyejung Won, Maria Kousi, Hilary K Finucane, Yakir Reshef, Lingyun Song, Alexias Safi, null null, Steven McCarroll, Benjamin M Neale, Roel A Ophoff, Michael C O'Donovan, Gregory E Crawford, Daniel H Geschwind, Nicholas Katsanis, Patrick F Sullivan, Bogdan Pasaniuc, Alkes L Price
Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nature genetics 50 (4) (2018)
Farhad Hormozdiari, Steven Gazal, Bryce van de Geijn, Hilary K Finucane, Chelsea J-T Ju, Po-Ru Loh, Armin Schoech, Yakir Reshef, Xuanyao Liu, Luke O'Connor, Alexander Gusev, Eleazar Eskin, Alkes L Price
Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. Nature genetics 50 (7) (2018)
Nicholas Mancuso, Simon Gayther, Alexander Gusev, Quan Long, Kathryn L Penney, Zsofia Kote-Jarai, Rosalind A Eeles, Matthew Freedman, Christopher Haiman, Bogdan Pasaniuc, null null
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions. Nature communications 9 (1) (2018)
Lang Wu, Wei Shi, Jirong Long, Xingyi Guo, Kyriaki Michailidou, Jonathan Beesley, Manjeet K Bolla, Xiao-Ou Shu, Yingchang Lu, Qiuyin Cai, Fares Al-Ejeh, Esdy Rozali, Qin Wang, Joe Dennis, Bingshan Li, Chenjie Zeng, Helian Feng, Alexander Gusev, Richard T Barfield, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J Aronson, Paul L Auer, Myrto Barrdahl, Caroline Baynes, Matthias W Beckmann, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Hiltrud B Brauch, Hermann Brenner, Louise Brinton, Per Broberg, Sara Y Brucker, Barbara Burwinkel, Trinidad Caldés, Federico Canzian, Brian D Carter, J Esteban Castelao, Jenny Chang-Claude, Xiaoqing Chen, Ting-Yuan David Cheng, Hans Christiansen, Christine L Clarke, null null, J Margriet Collée, Sten Cornelissen, Fergus J Couch, David Cox, Angela Cox, Simon S Cross, Julie M Cunningham, Kamila Czene, Mary B Daly, Peter Devilee, Kimberly F Doheny, Thilo Dörk, Isabel Dos-Santos-Silva, Martine Dumont, Miriam Dwek, Diana M Eccles, Ursula Eilber, A Heather Eliassen, Christoph Engel, Mikael Eriksson, Laura Fachal, Peter A Fasching, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Susan M Gapstur, Montserrat García-Closas, Mia M Gaudet, Maya Ghoussaini, Graham G Giles, Mark S Goldberg, David E Goldgar, Anna González-Neira, Pascal Guénel, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Emily Hallberg, Ute Hamann, Patricia Harrington, Alexander Hein, Belynda D Hicks, Peter Hillemanns, Antoinette Hollestelle, Robert N Hoover, John L Hopper, Guanmengqian Huang, Keith Humphreys, David J Hunter, Anna Jakubowska, Wolfgang Janni, Esther M John, Nichola Johnson, Kristine Jones, Michael E Jones, Audrey Jung, Rudolf Kaaks, Michael J Kerin, Elza K Khusnutdinova, Veli-Matti Kosma, Vessela N Kristensen, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Sara Lindström, Jolanta Lissowska, Wing-Yee Lo, Sibylle Loibl, Jan Lubinski, Craig Luccarini, Michael P Lux, Robert J MacInnis, Tom Maishman, Ivana Maleva Kostovska, Arto Mannermaa, JoAnn E Manson, Sara Margolin, Dimitrios Mavroudis, Hanne Meijers-Heijboer, Alfons Meindl, Usha Menon, Jeffery Meyer, Anna Marie Mulligan, Susan L Neuhausen, Heli Nevanlinna, Patrick Neven, Sune F Nielsen, Børge Grønne Nordestgaard, Olufunmilayo I Olopade, Janet E Olson, Håkan Olsson, Paolo Peterlongo, Julian Peto, Dijana Plaseska-Karanfilska, Ross Prentice, Nadege Presneau, Katri Pylkäs, Brigitte Rack, Paolo Radice, Nazneen Rahman, Gadi Rennert, Hedy S Rennert, Valerie Rhenius, Atocha Romero, Jane Romm, Anja Rudolph, Emmanouil Saloustros, Dale P Sandler, Elinor J Sawyer, Marjanka K Schmidt, Rita K Schmutzler, Andreas Schneeweiss, Rodney J Scott, Christopher G Scott, Sheila Seal, Mitul Shah, Martha J Shrubsole, Ann Smeets, Melissa C Southey, John J Spinelli, Jennifer Stone, Harald Surowy, Anthony J Swerdlow, Rulla M Tamimi, William Tapper, Jack A Taylor, Mary Beth Terry, Daniel C Tessier, Abigail Thomas, Kathrin Thöne, Rob A E M Tollenaar, Diana Torres, Thérèse Truong, Michael Untch, Celine Vachon, David Van Den Berg, Daniel Vincent, Quinten Waisfisz, Clarice R Weinberg, Camilla Wendt, Alice S Whittemore, Hans Wildiers, Walter C Willett, Robert Winqvist, Alicja Wolk, Lucy Xia, Xiaohong R Yang, Argyrios Ziogas, Elad Ziv, null null, Alison M Dunning, Paul D P Pharoah, Jacques Simard, Jonathan Beesley, Stacey L Edwards, Peter Kraft, Douglas F Easton, Georgia Chenevix-Trench, Quan Long
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. Nature genetics 50 (7) (2018)

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Alexander Gusev