NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers.

Chrissie E B Ong Amanda L Patchett Jocelyn M DarbyJinying ChenGuei-Sheung Liu A Bruce Lyons Gregory M Woods Andrew S Flies

Published in: Journal of cancer research and clinical oncology (2021)

MHC-I could be identified as a target for anti-tumor and allogeneic immunity. Consequently, NLRC5 could be a promising target for immunotherapy and vaccines to protect devils from transmissible cancers and inform development of transplant and cancer therapies for humans.

Keyphrases

stem cell transplantation
poor prognosis
papillary thyroid
bone marrow
low dose
long non coding rna
binding protein
high dose
lymph node metastasis