Autoantibodies to N-Terminally Truncated GAD65(96-585): HLA Associations and Predictive Value for Type 1 Diabetes.

Petra M PöllänenTaina HärkönenJorma Ilonen Jorma ToppariRiitta VeijolaHeli SiljanderOlli H Laitinen

Published in: The Journal of clinical endocrinology and metabolism (2021)

Autoantibodies to N-terminally truncated GAD improve the screening for T1D compared to f-GADA and may facilitate the selection of participants for clinical trials. HLA class II-mediated antigen presentation of GAD(96-585)-derived or structurally similar peptides might comprise an important pathomechanism in T1D.

Keyphrases

type diabetes
clinical trial
systemic lupus erythematosus
cardiovascular disease
glycemic control
randomized controlled trial
insulin resistance
case report
adipose tissue
phase ii
study protocol
amino acid
metabolic syndrome
phase iii