Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients.
Xueting YaoXiaoyu YanXiaohan WangTing CaiShun ZhangCheng CuiXiaoxu WangZhe HouQi LiuHaiyan LiJing LinZi XiongDongyang LiuPublished in: European journal of clinical pharmacology (2020)
Model-based simulation using PK parameters from the COVID-19 patients shows that the concentrations under the currently recommended dosing regimen are below the safety margin for side-effects, which suggests that these dosing regimens are generally safe. The derived population PK model should allow for the assessment of pharmacokinetics-pharmacodynamics (PK-PD) relationships for CQ when given alone or in combination with other agents to treat COVID-19.