Peroxisome proliferator-activated receptor gamma controls prostate cancer cell growth through AR-dependent and independent mechanisms.

Catherine C ElixMeghan M SalgiaMaya Otto-DuesselBen T CopelandChristopher YooMichael LeeBen Yi TewDavid AnnSumanta K PalJeremy O Jones

Published in: The Prostate (2019)

Having elucidated the direct cancer cell effects of PPARγ inhibition, our studies have helped to determine the role of PPARγ in PC growth, and support the hypothesis that PPARγ inhibition is an effective strategy for PC treatment.

Keyphrases

prostate cancer
insulin resistance
fatty acid
radical prostatectomy
combination therapy
metabolic syndrome