Organocatalytic Activation of Inert Hydrosilane for Peptide Bond Formation.

Published in: Organic letters (2022)

We describe the development of a reliable catalytic protocol for peptide bond formation that is generally applicable to natural and unnatural α-amino acids, β-amino acids, and peptides bearing various functional groups. A 10 mol % loading of HSi[OCH(CF3)2]3 as a catalyst was sufficient to guarantee a consistently high yield of the resulting peptide. This method facilitates the sustainable utilization of natural resources by using a catalyst and an auxiliary based on earth-abundant silicon.

Keyphrases

amino acid
room temperature
highly efficient
randomized controlled trial
cystic fibrosis
reduced graphene oxide
metal organic framework
carbon dioxide
crystal structure
electron transfer