Exercise training ameliorates bleomycin-induced epithelial mesenchymal transition and lung fibrosis through restoration of H2 S synthesis.

Shu-Fang DuXiu-Li WangChang-Lin YeZe-Jia HeDong-Xia LiBai-Ren DuYu-Jian LiuXiao-Yan Zhu

Published in: Acta physiologica (Oxford, England) (2018)

Exercise training restores bleomycin-induced downregulation of pulmonary CBS/CSE expression, thus contributing to the increased H2 S generation and suppression of TGF-β1/Smad and LRP-6/β-catenin signalling pathways, EMT and lung fibrosis.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
signaling pathway
high glucose
diabetic rats
skeletal muscle
cell proliferation
poor prognosis
drug induced
pulmonary hypertension
pulmonary fibrosis
oxidative stress
endothelial cells
stress induced