Myogenesis modelled by human pluripotent stem cells: a multi-omic study of Duchenne myopathy early onset.

Virginie Mournetas Emmanuelle Massourides Jean-Baptiste Dupont Etienne Kornobis Hélène Polvèche Margot Jarrige Alan R L Dorval Maxime R F Gosselin Antigoni Manousopoulou Spiros D D Garbis Dariusz C Górecki Christian Pinset

Published in: Journal of cachexia, sarcopenia and muscle (2021)

Our data argue for an early developmental manifestation of DMD whose onset is triggered before the entry into the skeletal muscle compartment, data leading to a necessary reconsideration of dystrophin roles during muscle development. This hiPSC model of skeletal muscle differentiation offers the possibility to explore these functions as well as find earlier DMD biomarkers and therapeutic targets.

Keyphrases

skeletal muscle
muscular dystrophy
pluripotent stem cells
early onset
duchenne muscular dystrophy
late onset
insulin resistance
electronic health record
big data
endothelial cells
type diabetes
deep learning