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Anticancer effects of mifepristone on human uveal melanoma cells.

Prisca Bustamante AlvarezAlexander LaskarisAlicia A GoyenecheYunxi ChenCarlos M TelleriaJulia Valdemarin Burnier
Published in: Cancer cell international (2021)
This study demonstrates that MF impedes the proliferation of UM cells in a concentration-dependent manner. We report that MF treatment at lower concentrations results in cell growth arrest, while increasing the concentration leads to lethality. MF, which has a good safety profile, could be a reliable adjuvant of a repurposing therapy against UM.
Keyphrases
  • induced apoptosis
  • endothelial cells
  • signaling pathway
  • cell cycle arrest
  • early stage
  • induced pluripotent stem cells
  • cell cycle
  • stem cells
  • endoplasmic reticulum stress
  • pluripotent stem cells
  • cell death
  • pi k akt