Genes regulating levels of ω-3 long-chain polyunsaturated fatty acids are associated with alcohol use disorder and consumption, and broader externalizing behavior in humans.

Fazil AlievPeter B BarrAndrew G DaviesDanielle M Dick Jill C Bettinger

Published in: Alcoholism, clinical and experimental research (2022)

Taken together with observations that dietary ω-3 LC-PUFAs can affect ethanol-related phenotypes, this work suggests that these fatty acids provide a link between the environmental and genetic influences on the risk of developing AUD.

Keyphrases

alcohol use disorder
genome wide
fatty acid
simultaneous determination
dna methylation
human health
bioinformatics analysis
mass spectrometry
gene expression
risk assessment
transcription factor
climate change
drug induced