Sugar Modification Enhances Cytotoxic Activity of PAMAM-Doxorubicin Conjugate in Glucose-Deprived MCF-7 Cells - Possible Role of GLUT1 Transporter.

Krzysztof SztanderaPaula DziałakMonika MarcinkowskaMaciej StańczykMichał GorzkiewiczAnna JanaszewskaBarbara Klajnert-Maculewicz

Published in: Pharmaceutical research (2019)

Our findings revealed that the glucose moiety plays a crucial role in the recognition of cells with high expression of GLUT receptors. By selectively blocking GLUT1 transporter we showed its importance for the cytotoxic activity of PAMAM-dox-glc conjugate. These results suggest that PAMAM-glucose formulations may constitute an efficient platform for the specific delivery of anticancer drugs to tumor cells overexpressing transporters of GLUT family.

Keyphrases

induced apoptosis
cell cycle arrest
blood glucose
cancer therapy
poor prognosis
endoplasmic reticulum stress
oxidative stress
type diabetes
signaling pathway
single cell
breast cancer cells
skeletal muscle
binding protein
drug induced