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Palladium-Catalyzed Cyanation of Aryl Sulfonium Salts.

Mengna LiuBenqiang CuiChuntao ZhongYanhui ShiYanfeng DangChangsheng Cao
Published in: Organic letters (2023)
A palladium-catalyzed cyanation of aryl dimethylsulfonium salts using cheap, nontoxic, and bench-stable K 4 [Fe(CN) 6 ]·3H 2 O as the cyanating reagent has been developed. The reactions proceeded well under base-free conditions with various sulfonium salts and provided aryl nitrile with yields of up to 92%. Aryl sulfides can be transformed to aryl nitriles directly via a one-pot process, and the protocol is scalable. Density functional theory calculations were performed to investigate the reaction mechanism that involved a catalytic cycle involving oxidative addition, ligand exchange, reductive elimination, and regeneration to yield the product.
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