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Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization.

Kehan ZhangPaige E CloonanSubramanian SundaramFeng LiuShoshana L DasJourdan K EwoldtJennifer L BaysSamuel TompChristopher N ToepferJúlia D C MarsigliaJoshua M GorhamDaniel ReichartJeroen EyckmansJonathan G SeidmanChristine E SeidmanChristopher S Chen
Published in: Science advances (2021)
[Figure: see text].
Keyphrases
  • copy number
  • left ventricular
  • smoking cessation
  • smooth muscle
  • heart failure