Joshua M Gorham (Josh Gorham, Joshua Gorham)

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 25

Top Topics

Hypertrophic Cardiomyopathy

Congenital Heart Disease

Top Venues

Nature medicine

Nature genetics

Circulation. Genomic and precision medicine

Research square

This page only lists publications with an associated author ORCID identifier.

Publications

Feng Xiao, Xiaoran Zhang, Sarah U Morton, Seong Won Kim, Youfei Fan, Joshua M Gorham, Huan Zhang, Paul J Berkson, Neil Mazumdar, Yangpo Cao, Jian Chen, Jacob Hagen, Xujie Liu, Pingzhu Zhou, Felix Richter, Yufeng Shen, Tarsha Ward, Bruce D Gelb, Jonathan G Seidman, Christine E Seidman, William T Pu
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. Nature genetics 56 (3) (2024)
Feng Xiao, Xiaoran Zhang, Sarah U Morton, Seong Won Kim, Youfei Fan, Joshua M Gorham, Huan Zhang, Paul J Berkson, Neil Mazumdar, Yangpo Cao, Jian Chen, Jacob Hagen, Xujie Liu, Pingzhu Zhou, Felix Richter, Yufeng Shen, Tarsha Ward, Bruce D Gelb, Jonathan G Seidman, Christine E Seidman, William T Pu
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. Nature genetics 56 (3) (2024)
Feng Xiao, Xiaoran Zhang, Sarah U Morton, Seong Won Kim, Youfei Fan, Joshua M Gorham, Huan Zhang, Paul J Berkson, Neil Mazumdar, Yangpo Cao, Jian Chen, Jacob Hagen, Xujie Liu, Pingzhu Zhou, Felix Richter, Yufeng Shen, Tarsha Ward, Bruce D Gelb, Jonathan G Seidman, Christine E Seidman, William T Pu
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. Nature genetics 56 (3) (2024)
Wei Ruan, Tao Li, Jaewoong Lee, In Hyuk Bang, Wankun Deng, Xinxin Ma, Seung-Hee Yoo, Boyun Kim, Jiwen Li, Xiaoyi Yuan, Yu A An, Yin-Ying Wang, Yafen Liang, Matthew Deberge, Dongze Zhang, Zhen Zhou, Yanyu Wang, Joshua M Gorham, Jonathan G Seidman, Christine E Seidman, Sary F Aranki, Ragini Nair, Lei Li, Jagat Narula, Zhong-Ming Zhao, Alemayehu Abebe Gorfe, Jochen Daniel Muehlschlegel, Kuang-Lei Tsai, Holger K Eltzschig
The BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury. Research square (2024)
Feng Xiao, Xiaoran Zhang, Sarah U Morton, Seong Won Kim, Youfei Fan, Joshua M Gorham, Huan Zhang, Paul J Berkson, Neil Mazumdar, Yangpo Cao, Jian Chen, Jacob Hagen, Xujie Liu, Pingzhu Zhou, Felix Richter, Yufeng Shen, Tarsha Ward, Bruce D Gelb, Jonathan G Seidman, Christine E Seidman, William T Pu
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. Nature genetics 56 (3) (2024)
Holger K Eltzschig, Wei Ruan, Tao Li, Jaewoong Lee, In Hyuk Bang, Wankun Deng, Xinxin Ma, Seung-Hee Yoo, Boyun Kim, Jiwen Li, Xiaoyi Yuan, Yu An, Yin-Ying Wang, Yafen Liang, Matthew Deberge, Dongze Zhang, Zhen Zhou, Yanyu Wang, Joshua M Gorham, Jonathan G Seidman, Christine E Seidman, Sary Aranki, Ragini Nair, Lei Li, Jagat Narula, Zhong-Ming Zhao, Alemayehu Abebe Gorfe, Jochen Muehlschlegel, Kuang-Lei Tsai
The BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury. Research square (2024)
Feng Xiao, Xiaoran Zhang, Sarah U Morton, Seong Won Kim, Youfei Fan, Joshua M Gorham, Huan Zhang, Paul J Berkson, Neil Mazumdar, Yangpo Cao, Jian Chen, Jacob Hagen, Xujie Liu, Pingzhu Zhou, Felix Richter, Yufeng Shen, Tarsha Ward, Bruce D Gelb, Jonathan G Seidman, Christine E Seidman, William T Pu
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. Nature genetics (2024)
Daniel Reichart, Gregory A Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M Gorham, Justin J Curran, Aditya Raguram, Daniel M DeLaughter, David A Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, David C Page, Nerea Zabaleta, Luk Vandenberghe, David R Liu, Jonathan G Seidman, Christine E Seidman
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nature medicine 29 (2) (2023)
Daniel Reichart, Gregory A Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M Gorham, Justin J Curran, Aditya Raguram, Daniel M DeLaughter, David A Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, David C Page, Nerea Zabaleta, Luk Vandenberghe, David R Liu, Jonathan G Seidman, Christine E Seidman
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nature medicine (2023)
Daniel Reichart, Gregory A Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M Gorham, Justin J Curran, Aditya Raguram, Daniel M DeLaughter, David A Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, David C Page, Nerea Zabaleta, Luk Vandenberghe, David R Liu, Jonathan G Seidman, Christine E Seidman
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nature medicine 29 (2) (2023)
Daniel Reichart, Gregory A Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M Gorham, Justin J Curran, Aditya Raguram, Daniel M DeLaughter, David A Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, David C Page, Nerea Zabaleta, Luk Vandenberghe, David R Liu, Jonathan G Seidman, Christine E Seidman
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nature medicine 29 (2) (2023)
Daniel Reichart, Gregory A Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M Gorham, Justin J Curran, Aditya Raguram, Daniel M DeLaughter, David A Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, David C Page, Nerea Zabaleta, Luk Vandenberghe, David R Liu, Jonathan G Seidman, Christine E Seidman
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nature medicine 29 (2) (2023)
Daniel Reichart, Gregory A Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M Gorham, Justin J Curran, Aditya Raguram, Daniel M DeLaughter, David A Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, David C Page, Nerea Zabaleta, Luk Vandenberghe, David R Liu, Jonathan G Seidman, Christine E Seidman
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nature medicine 29 (2) (2023)
Sophie L V M Stroeks, Ida Gjervold Lunde, Debby M E I Hellebrekers, Godelieve R F Claes, Hiroko Wakimoto, Joshua M Gorham, Ingrid P C Krapels, Els K Vanhoutte, Arthur van den Wijngaard, Michiel T H M Henkens, Anne G Raafs, Maurits A Sikking, Jos L V Broers, Miranda Nabben, Elizabeth Anne Vincent Jones, Stephane R B Heymans, Han G Brunner, Job A J Verdonschot
Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy. Circulation. Genomic and precision medicine (2023)
Yuri Kim, Oddný Brattberg Gunnarsdóttir, Anissa Viveiros, Daniel Reichart, Daniel Quiat, Jon A L Willcox, Hao Zhang, Huachen Chen, Justin J Curran, Daniel H Kim, Simon Urschel, Barbara McDonough, Joshua M Gorham, Steven R DePalma, Jonathan G Seidman, Christine E Seidman, Gavin Y Oudit
Genetic Contribution to End-Stage Cardiomyopathy Requiring Heart Transplantation. Circulation. Genomic and precision medicine (2023)
Daniel Reichart, Gregory A Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M Gorham, Justin J Curran, Aditya Raguram, Daniel M DeLaughter, David A Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, David C Page, Nerea Zabaleta, Luk Vandenberghe, David R Liu, Jonathan G Seidman, Christine E Seidman
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nature medicine 29 (2) (2023)
Daniel Reichart, Gregory A Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M Gorham, Justin J Curran, Aditya Raguram, Daniel M DeLaughter, David A Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, David C Page, Nerea Zabaleta, Luk Vandenberghe, David R Liu, Jonathan G Seidman, Christine E Seidman
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nature medicine 29 (2) (2023)
Daniel Reichart, Gregory A Newby, Hiroko Wakimoto, Mingyue Lun, Joshua M Gorham, Justin J Curran, Aditya Raguram, Daniel M DeLaughter, David A Conner, Júlia D C Marsiglia, Sajeev Kohli, Lukas Chmatal, David C Page, Nerea Zabaleta, Luk Vandenberghe, David R Liu, Jonathan G Seidman, Christine E Seidman
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nature medicine 29 (2) (2023)
Radhika Agarwal, Hiroko Wakimoto, Joao A Paulo, Qi Zhang, Daniel Reichart, Christopher N Toepfer, Arun Sharma, Angela C Tai, Mingyue Lun, Joshua M Gorham, Steven R DePalma, Steven P Gygi, Jonathan G Seidman, Christine E Seidman
Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3 , an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere. Circulation 146 (22) (2022)
Daniel Reichart, Eric Lars-Helge Lindberg, Henrike Maatz, Antonio M A Miranda, Anissa Viveiros, Nikolay Shvetsov, Anna Gaertner, Emily R Nadelmann, Michael Lee, Kazumasa Kanemaru, Jorge Ruiz-Orera, Viktoria Strohmenger, Daniel M DeLaughter, Giannino Patone, Hao Zhang, Andrew Woehler, Christoph Lippert, Yuri Kim, Eleonora Adami, Joshua M Gorham, Sam N Barnett, Kemar J Brown, Rachel J Buchan, Rasheda A Chowdhury, Chrystalla Constantinou, James Cranley, Leanne E Felkin, Henrik Fox, Ahla Ghauri, Jan F Gummert, Masatoshi Kanda, Ruoyan Li, Lukas Mach, Barbara McDonough, Sara Samari, Farnoush Shahriaran, Clarence Yapp, Caroline Stanasiuk, Pantazis I Theotokis, Fabian Joachim Theis, Antoon van den Bogaerdt, Hiroko Wakimoto, James Simon Ware, Catherine L Worth, Paul J R Barton, Young-Ae Lee, Sarah A Teichmann, Andreas Brodehl, Michela Noseda, Gavin Y Oudit, Matthias Heinig, Jonathan G Seidman, Norbert Hübner, Christine E Seidman
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies. Science (New York, N.Y.) 377 (6606) (2022)
Kehan Zhang, Paige E Cloonan, Subramanian Sundaram, Feng Liu, Shoshana L Das, Jourdan K Ewoldt, Jennifer L Bays, Samuel Tomp, Christopher N Toepfer, Júlia D C Marsiglia, Joshua M Gorham, Daniel Reichart, Jeroen Eyckmans, Jonathan G Seidman, Christine E Seidman, Christopher S Chen
Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Science advances 7 (42) (2021)
Parth N Patel, Shefali S Verma, Jon A L Willcox, Alireza Haghighi, Min Young Jang, Joshua M Gorham, Steven R DePalma, Lien Lam, Barbara McDonough, Renee Johnson, Neal K Lakdawala, Amy E Roberts, Paul J R Barton, Stuart Alexander Cook, Diane Fatkin, Christine E Seidman, Jonathan G Seidman
Contribution of Noncanonical Splice Variants to TTN Truncating Variant Cardiomyopathy. Circulation. Genomic and precision medicine 14 (5) (2021)
Ronny Alcalai, Michael Arad, Hiroko Wakimoto, Dor Yadin, Joshua M Gorham, Libin Wang, Elia Burns, Barry J Maron, William C Roberts, Tetsuo Konno, David A Conner, Antonio R Perez-Atayde, Jon G Seidman, Christine E Seidman
LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart. Journal of the American Heart Association 10 (17) (2021)
Radhika Agarwal, Joao A Paulo, Christopher N Toepfer, Jourdan K Ewoldt, Subramanian Sundaram, Anant Chopra, Qi Zhang, Joshua M Gorham, Steven R DePalma, Christopher S Chen, Steven P Gygi, Christine E Seidman, Jonathan G Seidman
Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation. Circulation research 129 (7) (2021)
Christopher N Toepfer, Hiroko Wakimoto, Amanda C Garfinkel, Barbara McDonough, Dan Liao, Jianming Jiang, Angela C Tai, Joshua M Gorham, Ida Gjervold Lunde, Mingyue Lun, Thomas L Lynch, James W McNamara, Sakthivel Sadayappan, Charles S Redwood, Hugh C Watkins, Jonathan G Seidman, Christine E Seidman
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin. Science translational medicine 11 (476) (2020)