Probiotics for chronic low back pain with type 1 Modic changes: a randomized double-blind, placebo-controlled trial with 1-year follow-up using Lactobacillus Rhamnosis GG.

Ole Kudsk JensenMorten H AndersenRené D ØstgårdNiels T AndersenNanna Rolving

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2019)

No differences were found regarding the predefined outcomes. Overall, there was little improvement during the 1-year observation period. A small, though hardly clinically relevant, effect on back pain was seen after treatment by Lactobacillus Rhamnosis GG, and the treatment was without side effects in comparison with the control group.

Keyphrases

double blind
clinical trial
study protocol
randomized controlled trial
combination therapy
skeletal muscle
weight loss
glycemic control
clinical evaluation