Secreted factors derived from obese visceral adipose tissue regulate the expression of breast malignant transformation genes.

A B CrujeirasB CabiaM C CarreiraM AmilJ CuevaS AndradeL M SeoaneMaría PardoA SueiroJ BaltarT MoraisM P MonteiroR Lopez-LopezF F Casanueva

Published in: International journal of obesity (2005) (2015)

Lipid peroxides secreted by the obese visceral adipose tissue could be among the relevant factors that promote changes involved in the early steps of tumor development in mammary gland. These changes can be detected even before histological alterations and in circulating leukocytes.

Keyphrases

adipose tissue
insulin resistance
high fat diet
metabolic syndrome
poor prognosis
type diabetes
weight loss
genome wide
binding protein
gene expression
transcription factor
dna methylation
obese patients